Papers/PMID:41825226
Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
calciol — activates TREM2
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Functionally, cholecalciferol induced TREM2-dependent signaling in human, rat, and mouse cells.”
Quoted verbatim from Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2.. - Study
- in vitro · not in humans
- Population
- human, rat, and mouse macrophage and microglial cell cultures
Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2.2026PMID:41825226Permalink