Papers/PMID:41686719
The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.
Neuroimmunomodulation2026The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
acetylsalicylic acid — no detected effect on total leukocyte count
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“WBC counts in the sleep restriction/placebo condition were increased after 5 nights of sleep restriction compared to the control sleep/placebo condition, while there was no difference between the sleep restriction/ASA and the sleep restriction/placebo condition.”
Quoted verbatim from The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.. - Study
- crossover
- Dose
- 81 mg once daily in the evening for 14 at-home days then during the in-laboratory stay
- Population
- Healthy adults (age 19-63) under experimental sleep restriction, after 5 nights of restricted sleep (study day 8); daily low-dose aspirin versus placebo
The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.2026PMID:41686719Permalink
acetylsalicylic acid — no detected effect on CD4/CD8 ratio
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“The CD4/CD8 T-cell ratio was elevated after 5 nights of sleep restriction in the sleep restriction/placebo condition compared to control sleep/placebo, while there was no difference between sleep restriction/ASA and sleep restriction/placebo or control sleep/placebo.”
Quoted verbatim from The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.. - Study
- crossover
- Dose
- 81 mg once daily in the evening for 14 at-home days then during the in-laboratory stay
- Population
- Healthy adults (age 19-63) under experimental sleep restriction, after 5 nights of restricted sleep (study day 8); daily low-dose aspirin versus placebo
The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.2026PMID:41686719Permalink