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PapersPMID:41545342

NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.

Cell death & disease2026The record ↗

01 · findings
2
02 · compound
1
03 · endpoints
2
04 · null
0
  1. Hypothesis, insufficient evidencelowersFBXW7
  2. Hypothesis, insufficient evidencelowersSYVN1

What moved

2 findingsHow to read these marks →

  • all-cis-docosa-4,7,10,13,16,19-hexaenoic acid — inhibits FBXW7

    insufficientHypothesis

    “Mechanistically, DHA inhibited the ubiquitination of NRF1 via the cytoplasmic E3 ligases FBW7 and HRD1 at the ER membrane, thereby preventing its degradation.”
    Quoted verbatim from NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress..
    Study
    mechanistic · not in humans
    Population
    not stated in the abstract

    Permalink

  • all-cis-docosa-4,7,10,13,16,19-hexaenoic acid — inhibits SYVN1

    insufficientHypothesis

    “Mechanistically, DHA inhibited the ubiquitination of NRF1 via the cytoplasmic E3 ligases FBW7 and HRD1 at the ER membrane, thereby preventing its degradation.”
    Quoted verbatim from NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress..
    Study
    mechanistic · not in humans
    Population
    not stated in the abstract

    Permalink

Study record

Design, as each reading recorded it
in vitro / mechanistic study
Species
cells / mixed / none
Population
cultured hepatocytes (ubiquitination/degradation assay; exact cell line not stated in abstract)
Participants
not recorded
Comparator
not stated in the paper / placebo
Duration
140 days
Endpoints
3
Record
extracted
Readings recorded
2