Papers/PMID:41545342
NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.
Cell death & disease2026The record
2 findings drawn from this paper, on 1 compound across 2 endpoints.
What it reported
How to read these marksWhat moved
2 findings
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid — inhibits FBXW7
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Hypothesis“Mechanistically, DHA inhibited the ubiquitination of NRF1 via the cytoplasmic E3 ligases FBW7 and HRD1 at the ER membrane, thereby preventing its degradation.”
Quoted verbatim from NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.. - Study
- mechanistic · not in humans
- Population
- not stated in the abstract
NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.2026PMID:41545342
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid — inhibits SYVN1
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Hypothesis“Mechanistically, DHA inhibited the ubiquitination of NRF1 via the cytoplasmic E3 ligases FBW7 and HRD1 at the ER membrane, thereby preventing its degradation.”
Quoted verbatim from NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.. - Study
- mechanistic · not in humans
- Population
- not stated in the abstract
NRF1 is upregulated by docosahexaenoic acid to ameliorate MASH through the inhibition of ER stress.2026PMID:41545342