Papers/PMID:41490838
Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies.
Journal of advanced research2026The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
taurine — decreases alanine aminotransferase
Evidence strength: insufficient.Finding“The liver injury indicators, ALT and AST, were decreased significantly in taurine + APAP + ECWT group compared with the PBS + APAP + ECWT group, indicating that supplementation of taurine could alleviate AILI (Fig. S5B).”
Quoted verbatim from Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies.. - Study
- animal · not in humans
- Dose
- 300 mg/kg body weight by oral gavage before APAP injection, samples 24 h after APAP
- Population
- Male C57BL/6J mice given acetaminophen 300 mg/kg intraperitoneally followed by kpsM-positive E. coli gavage; taurine or PBS given by oral gavage before the acetaminophen
Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies.2026PMID:4149083810.1016/j.jare.2025.12.012Permalink
taurine — decreases aspartate aminotransferase
Evidence strength: insufficient.Finding“The liver injury indicators, ALT and AST, were decreased significantly in taurine + APAP + ECWT group compared with the PBS + APAP + ECWT group, indicating that supplementation of taurine could alleviate AILI (Fig. S5B).”
Quoted verbatim from Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies.. - Study
- animal · not in humans
- Dose
- 300 mg/kg body weight by oral gavage before APAP injection, samples 24 h after APAP
- Population
- Male C57BL/6J mice given acetaminophen 300 mg/kg intraperitoneally followed by kpsM-positive E. coli gavage; taurine or PBS given by oral gavage before the acetaminophen
Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies.2026PMID:4149083810.1016/j.jare.2025.12.012Permalink