Papers/PMID:41228512
The Effect of Maternal Folic Acid Supplementation on Neurodevelopmental Disorders in Offspring: An Umbrella Review of Systematic Reviews and Meta-Analyses.
Nutrients2025The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
folic acid — decreases autism spectrum disorder diagnosis (offspring)
Evidence strength: moderate.Finding“The MA indicated that maternal folic acid supplementation is associated with a significant reduction in the risk of offspring ASD (pooled OR = 0.66, 95% CI: 0.55–0.79), as shown in the forest plot.”
Quoted verbatim from The Effect of Maternal Folic Acid Supplementation on Neurodevelopmental Disorders in Offspring: An Umbrella Review of Systematic Reviews and Meta-Analyses.. - Study
- meta-analysis
- Population
- Offspring of mothers who did or did not take folic acid before and/or during pregnancy, pooled from 24 non-randomised studies (case-control, cohort and cross-sectional)
Effect 0.66 odds ratio, 95% CI 0.55 to 0.79
The Effect of Maternal Folic Acid Supplementation on Neurodevelopmental Disorders in Offspring: An Umbrella Review of Systematic Reviews and Meta-Analyses.2025PMID:4122851210.3390/nu17213443Permalink