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PapersPMID:41198662

The locking mechanism of human TRPV6 inhibition by intracellular magnesium.

Nature communications2025The record ↗

01 · finding
1
02 · compound
1
03 · endpoint
1
04 · null
0
  1. Finding, insufficient evidencelowersTRPV6

What moved

1 findingHow to read these marks →

  • magnesium(2+) — inhibits TRPV6

    insufficientFinding

    “When bound to the D489-D580 site, Mg2+ prevents the α-to-π transition in the middle of S6 that accompanies channel opening, thus maintaining S6 entirely α-helical, locking the channel in the closed state and inhibiting TRPV6-mediated currents.”
    Quoted verbatim from The locking mechanism of human TRPV6 inhibition by intracellular magnesium..
    Study
    in vitro · not in humans
    Population
    human TRPV6 channel, cryo-EM, mutagenesis and electrophysiology

    Permalink

Study record

Read under
magnesium(2+)
Design, as each reading recorded it
in vitro / mechanistic study
Species
cells / none
Population
HEK 293 and HEK 293T cells expressing human TRPV6
Participants
not recorded
Comparator
another dose / not stated in the paper
Duration
not recorded
Endpoints
1
Record
extracted
Readings recorded
2