Papers/PMID:41198662
The locking mechanism of human TRPV6 inhibition by intracellular magnesium.
Nature communications2025The record
1 finding drawn from this paper, on 1 compound across 1 endpoint.
What it reported
How to read these marksWhat moved
1 finding
magnesium(2+) — inhibits TRPV6
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“When bound to the D489-D580 site, Mg2+ prevents the α-to-π transition in the middle of S6 that accompanies channel opening, thus maintaining S6 entirely α-helical, locking the channel in the closed state and inhibiting TRPV6-mediated currents.”
Quoted verbatim from The locking mechanism of human TRPV6 inhibition by intracellular magnesium.. - Study
- in vitro · not in humans
- Population
- human TRPV6 channel, cryo-EM, mutagenesis and electrophysiology
The locking mechanism of human TRPV6 inhibition by intracellular magnesium.2025PMID:41198662