magnesium(2+)/Finding
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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits TRPV6
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“When bound to the D489-D580 site, Mg2+ prevents the α-to-π transition in the middle of S6 that accompanies channel opening, thus maintaining S6 entirely α-helical, locking the channel in the closed state and inhibiting TRPV6-mediated currents.”
Quoted verbatim from The locking mechanism of human TRPV6 inhibition by intracellular magnesium.. - Study
- in vitro · not in humans
- Population
- human TRPV6 channel, cryo-EM, mutagenesis and electrophysiology
The locking mechanism of human TRPV6 inhibition by intracellular magnesium.2025PMID:41198662Permalink
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To cite this finding: https://catalystproject.ai/e/01M2TBZG9EGPAAQ747NF1ZEP3Z