Papers/PMID:41051561
Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.
Intensive care medicine2025The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
melatonin — no detected effect on incidence of ICU delirium
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Our primary analysis was based on six RCTs with 2209 patients and did not show any difference in the incidence of delirium attributable to the treatment with melatonin (RR 0.89, [95% confidence interval (CI) 0.73-1.09]).”
Quoted verbatim from Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Participants
- 2,209
- Population
- critically ill patients in intensive care units
Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.2025PMID:41051561Permalink
melatonin — no detected effect on all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“No association was found between mortality and melatonin in the primary (seven RCTs, 2165 patients, RR 0.87, [95% CI 0.73-1.02]) and secondary (8 RCTs, 2396 patients, RR 0.92, [95% CI 0.79-1.06]) analyses.”
Quoted verbatim from Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Participants
- 2,165
- Population
- critically ill patients in intensive care units
Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials.2025PMID:41051561Permalink