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PapersPMID:41049366

The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised cross-over trial.

Frontiers in nutrition2025The record ↗

  1. Finding, very limited evidenceno difference foundCortisol concentration

No finding here moved its endpoint.

What did not

1 findingHow to read these marks →
  • “Salivary cortisol values did not change between PEA and placebo treatment arms.”
    Study
    crossover
    Participants
    16
    Duration
    6 weeks
    Interests
    Industry funded
    Dose studied
    Levagen+ (formulated PEA), 600 mg PEA per day as two capsules taken together, oral, 6 weeks
    Population
    Moderately stressed female university students (PSS above 13) in London, a sub-study of a larger trial; randomised double-blind placebo-controlled crossover, 6-week arms; placebo was microcrystalline cellulose; saliva collected on waking, 7 to 8 am

Study record

Design
crossover trial
Species
human
Population
moderately stressed (PSS > 13) female university students, BMI 20 to 30
Participants
16
Comparator
placebo
Duration
42 days
Endpoints measured
13