Skip to content
Catalyst

N-hexadecanoylethanolamineFinding

N-hexadecanoylethanolamine has no detected effect on cortisol concentration

no difference foundVery limited evidenceFinding

01 · The sentence it was drawn from

“Salivary cortisol values did not change between PEA and placebo treatment arms.”
Quoted verbatim from The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised cross-over trial.
This finding among the 6 findings on its endpoint

N-hexadecanoylethanolamine

Cortisol concentration

no difference found

Who
n = 16 · Moderately stressed female university students (PSS above 13) in London, a sub-study of a larger trial; randomised double-blind placebo-controlled crossover, 6-week arms; placebo was microcrystalline cellulose; saliva collected on waking, 7 to 8 am
Dose studied
Levagen+ (formulated PEA), 600 mg PEA per day as two capsules taken together, oral, 6 weeks

Very limited evidencePMID 41049366 · 2025

02 · The study

Study
crossover
Participants
16
Duration
6 weeks

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

Frontiers in nutrition
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M70G367R03TZPVWT3FFDEFJG