Papers/PMID:40898469
Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.
Medicine2025The record
3 findings · 1 compound · 3 endpoints · 2 null
What it reported
How to read these marksWhat moved
1 finding
selenium atom — decreases serum thyroid peroxidase antibody (TPOAb) titre
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“We found that the TPOAb levels of HT patients who received Se supplementation decreased significantly after 3 months (SMD = −0.46, 95% CI: −0.74 to −0.18, P =.001) and after 6 months (SMD = −0.80, 95% CI: −1.38 to −0.21, P =.008).”
Quoted verbatim from Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- typically 200 μg/d
- Population
- Adults with Hashimoto thyroiditis, with or without levothyroxine; selenium (selenomethionine, selenoyeast or sodium selenate) against placebo, no treatment or levothyroxine alone; 6-month timepoint estimate recorded
Effect -0.8 standardised mean difference, 95% CI -1.38 to -0.21
Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.2025PMID:40898469Permalink
What did not
2 findings
selenium atom — no detected effect on serum free triiodothyronine (FT3)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The meta-analysis found no statistically significant difference in FT3 and FT4 level after 3 or 6 months of Se treatment (Fig. S1, Supplemental Digital Content, https://links.lww.com/MD/P797).”
Quoted verbatim from Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- typically 200 μg/d
- Population
- Adults with Hashimoto thyroiditis, with or without levothyroxine; selenium against placebo, no treatment or levothyroxine alone; 3- and 6-month timepoints
Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.2025PMID:40898469Permalink
selenium atom — no detected effect on serum free thyroxine (FT4)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The meta-analysis found no statistically significant difference in FT3 and FT4 level after 3 or 6 months of Se treatment (Fig. S1, Supplemental Digital Content, https://links.lww.com/MD/P797).”
Quoted verbatim from Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- typically 200 μg/d
- Population
- Adults with Hashimoto thyroiditis, with or without levothyroxine; selenium against placebo, no treatment or levothyroxine alone; 3- and 6-month timepoints
Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.2025PMID:40898469Permalink