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PapersPMID:40827100

Effect of sodium balance on levels of nitrates in healthy subjects: Posthoc analysis of a randomized, double-blinded, placebo-controlled, crossover study.

Physiological reports2025The record ↗

  1. Finding, limited evidencelowersPlasma nitrate concentration

What moved

1 findingHow to read these marks →
  • “Plasma nitrate was significantly lower following high sodium intake compared with low sodium intake (p = 0.019).”
    Study
    crossover
    Duration
    4 days
    Dose studied
    200 mmol sodium per day as sodium chloride enterotablets in 16 gelatin capsules, taken three times daily for 4 days
    Population
    27 healthy adults (14 men, 13 women; age 27 ± 7 years) in a randomised, double-blinded crossover study; both periods followed a standardised diet of about 100 mmol sodium per day for 4 days, with sodium chloride capsules in one period and a potato-starch and lactose placebo in the other; fasting morning sample on the examination day

Study record

Design
crossover trial
Species
human
Population
healthy subjects on a 4-day low-sodium diet with sodium chloride tablets or placebo
Participants
27
Comparator
placebo
Duration
4 days
Endpoints measured
38