Papers/PMID:39614357
Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis.
Critical care (London, England)2024The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
thiamine — decreases all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“Overall in-hospital mortality was not the same across the three treatment groups, with a lower mortality observed in patients in group B1 compared to the control group (hazard ratio 0.8, 95% confidence interval [0.67;0.94], p = 0.008, Fig. 1 and Supplementary Fig. 2).”
Quoted verbatim from Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis.. - Study
- cohort
- Population
- Adult ICU patients with sepsis or septic shock at two Swiss university hospitals, 2012-2022; B1 group (n = 1054) versus control group on standard treatment without B1 or ascorbic acid (n = 2183); oral and intravenous thiamine pooled; all clusters combined; all-cause in-hospital mortality
Effect 0.8 hazard ratio, 95% CI 0.67 to 0.94
Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis.2024PMID:39614357Permalink