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PapersPMID:39574288

Methylene Blue for Septic Shock: A Systematic Review and Meta-analysis of Randomized and Prospective Observational Studies.

Journal of intensive care medicine2026The record ↗

01 · finding
1
02 · compound
1
03 · endpoint
1
04 · null
0
  1. Finding, very limited evidencelowersAll-cause mortality

What moved

1 findingHow to read these marks →
  • methylene blue — decreases all-cause mortality

    very limitedFindingreplicated ×2

    “The meta-analysis showed statistically significant reduction in mortality rates among septic shock patients treated with MB (mortality rate 0.52; 95% CI 0.38 to 0.66; P < .001).”
    Quoted verbatim from Methylene Blue for Septic Shock: A Systematic Review and Meta-analysis of Randomized and Prospective Observational Studies.
    Study
    meta-analysis
    Population
    adult ICU patients with septic shock; pooled across 15 studies (5 RCT, 10 non-randomized)

    Permalink

Study record

Read under
methylene blue
Design
meta-analysis
Species
human
Population
Adult patients with septic shock in the ICU receiving intravenous methylene blue; 15 studies (5 randomized, 10 non-randomized)
Participants
441
Comparator
not stated in the paper
Duration
not recorded
Endpoints measured
7
Record
declined
Declined
another reason, stated per paper
Readings recorded
1