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PapersPMID:38960833

Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.

British journal of anaesthesia2024The record ↗

01 · finding
1
02 · compound
1
03 · endpoint
1
04 · null
0
  1. Finding, insufficient evidencelowersInterleukin-6 concentration

What moved

1 findingHow to read these marks →

  • sodium ascorbate — decreases interleukin-6 concentration

    insufficientFinding

    “Sodium ascorbate slightly reduced the sepsis-induced increase in interleukin-6, returned VEGF-A to normal (both PGroupxTime<0.01), and increased plasma ascorbate (20 000 [300] μM; PGroup<0.001).”
    Quoted verbatim from Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis..
    Study
    animal · not in humans
    Dose studied
    0.5 g/kg IV over 30 min followed by 0.5 g/kg/h for 6.5 h
    Population
    unanaesthetised Merino ewes with Gram-negative (E. coli) sepsis, megadose sodium ascorbate IV arm

    Permalink

Study record

Design, as each reading recorded it
animal study, in vivo / randomised controlled trial
Species
animal
Population
unanaesthetised Merino ewes with Gram-negative (E. coli) sepsis, megadose sodium ascorbate IV arm
Participants
12
Comparator
not stated in the paper
Duration
not recorded
Endpoints
5
Record
declined
Declined
this platform holds no node for the endpoint
Readings recorded
2