Papers/PMID:38960833
Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.
British journal of anaesthesia2024The record
1 finding drawn from this paper, on 1 compound across 1 endpoint.
What it reported
How to read these marksWhat moved
1 finding
sodium ascorbate — decreases interleukin-6 concentration
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Sodium ascorbate slightly reduced the sepsis-induced increase in interleukin-6, returned VEGF-A to normal (both PGroupxTime<0.01), and increased plasma ascorbate (20 000 [300] μM; PGroup<0.001).”
Quoted verbatim from Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg IV over 30 min followed by 0.5 g/kg/h for 6.5 h
- Population
- unanaesthetised Merino ewes with Gram-negative (E. coli) sepsis, megadose sodium ascorbate IV arm
Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.2024PMID:38960833