sodium ascorbate/Finding
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Decreases interleukin-6 concentration
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Sodium ascorbate slightly reduced the sepsis-induced increase in interleukin-6, returned VEGF-A to normal (both PGroupxTime<0.01), and increased plasma ascorbate (20 000 [300] μM; PGroup<0.001).”
Quoted verbatim from Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg IV over 30 min followed by 0.5 g/kg/h for 6.5 h
- Population
- unanaesthetised Merino ewes with Gram-negative (E. coli) sepsis, megadose sodium ascorbate IV arm
Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.2024PMID:38960833Permalink
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To cite this finding: https://catalystproject.ai/e/01M2T78CT28RAKZPEC5W3SX96T