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PapersPMID:38844675

The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial.

Sports medicine - open2024The record ↗

findings
2
compound
1
endpoints
2
  1. Finding, moderate evidenceno difference foundLean body mass
  2. Finding, moderate evidenceno difference foundBody mass
Study, every finding
RCT · 48 participants · 8 weeks
Dose studied, every finding
Levagen+ 175 mg capsule (not less than 150 mg PEA) twice daily, oral, 8 weeks

No finding here moved its endpoint.

  • “Lean mass increased by 2.0 ± 2.0% and 2.4 ± 2.1% in the PEA and PLA groups respectively, with no significant differences between groups (ITT: p = 0.38; PP: p = 0.39; Table 2; Fig. 3C).”
    Interests
    Industry funded
    Population
    Healthy, untrained, recreationally active adults aged 18-35 y; both arms did the same supervised 8-week resistance training programme with a standardised pre-workout snack and a post-session protein beverage; placebo was maltodextrin; intention-to-treat analysis
  • “Body mass increased in both groups over the 8 weeks (PEA: 0.6 ± 1.4 kg; PLA: 1.0 ± 1.8 kg), with no significant difference between groups (Table 2; Fig. 3B).”
    Interests
    Industry funded
    Population
    Healthy, untrained, recreationally active adults aged 18-35 y; both arms did the same supervised 8-week resistance training programme; placebo was maltodextrin; intention-to-treat analysis

Study record

Design
randomised controlled trial
Species
human
Population
healthy, recreationally active, untrained adults undergoing 8 weeks of resistance training
Participants
52
Comparator
placebo
Duration
56 days
Endpoints measured
77