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PapersPMID:38750013

Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor.

Nature communications2024The record ↗

01 · finding
1
02 · compound
1
03 · endpoint
1
04 · null
0
  1. Hypothesis, insufficient evidencelowersRYR1

What moved

1 findingHow to read these marks →

  • magnesium(2+) — inhibits RYR1

    insufficientHypothesis

    “Notably, Mg2+ inhibits RyR1 by interacting with the gating helices as validated by molecular dynamics.”
    Quoted verbatim from Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor..
    Study
    mechanistic · not in humans
    Population
    RyR1, cryo-EM structure with Mg2+ and molecular dynamics simulation

    Permalink

Study record

Read under
magnesium(2+)
Design
mechanistic study
Species
animal / none
Population
rabbit skeletal muscle sarcoplasmic reticulum (RyR1) membrane vesicles, reconstituted in nanodiscs
Participants
not recorded
Comparator
another dose / not stated in the paper
Duration
not recorded
Endpoints
1
Record
declined
Declined
another reason, stated per paper
Readings recorded
2