Papers/PMID:38750013
Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor.
Nature communications2024The record
1 finding drawn from this paper, on 1 compound across 1 endpoint.
What it reported
How to read these marksWhat moved
1 finding
magnesium(2+) — inhibits RYR1
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Hypothesis“Notably, Mg2+ inhibits RyR1 by interacting with the gating helices as validated by molecular dynamics.”
Quoted verbatim from Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor.. - Study
- mechanistic · not in humans
- Population
- RyR1, cryo-EM structure with Mg2+ and molecular dynamics simulation
Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor.2024PMID:38750013