magnesium(2+)/Finding
One finding, on its own
A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits RYR1
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Hypothesis“Notably, Mg2+ inhibits RyR1 by interacting with the gating helices as validated by molecular dynamics.”
Quoted verbatim from Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor.. - Study
- mechanistic · not in humans
- Population
- RyR1, cryo-EM structure with Mg2+ and molecular dynamics simulation
Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor.2024PMID:38750013Permalink
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- Everything the graph holds on magnesium(2+)
- Every compound studied against RYR1
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To cite this finding: https://catalystproject.ai/e/01M2TBZGK8NTRGPGX4QH4XW3Z8