paroxetine/Finding
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Increases antidepressant treatment response rate
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Paroxetine therapy for dPD markedly increased the antidepressant response rate (OR 3.62, 95% CI 2.63 to 4.98, P <.00001).”
Quoted verbatim from The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.. - Study
- meta-analysis
- Dose
- 20 mg/d in most trials
- Population
- Patients with depression and idiopathic Parkinson's disease; paroxetine added to background anti-parkinsonian drug therapy versus that therapy alone (or placebo in 3 trials); 22 trials, 1808 participants
Effect 3.62 odds ratio, 95% CI 2.63 to 4.98
The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis.2023PMID:37653795Permalink
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To cite this finding: https://catalystproject.ai/e/01M45E79TWQ14HQPM2E0TTPH30