Papers/PMID:36897714
Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.
Medicine2023The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
duloxetine — decreases visual analogue scale pain intensity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Pooled data shows that duloxetine can reduce postoperative VAS at movement (MD = −1.08; 95% CI, [−1.45–−0.7]; P <.05. Fig. 5).”
Quoted verbatim from Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Adults after a first total knee arthroplasty; six pooled randomised trials of perioperative duloxetine versus placebo; pain on movement pooled across postoperative timepoints from 24 hours to 5 days
Effect -1.08 mean difference, 95% CI -1.45 to -0.7
Effect of duloxetine on pain relief after total knee arthroplasty: A meta-analysis of randomized controlled trials.2023PMID:36897714Permalink