Papers/PMID:36113465
Structure and mechanism of human cystine exporter cystinosin.
Cell2022The record
1 finding drawn from this paper, on 1 compound across 1 endpoint.
What it reported
How to read these marksWhat moved
1 finding
L-cystine — binds CTNS
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Hypothesis“Here, we present structures of human cystinosin in lumen-open, cytosol-open, and cystine-bound states, which uncover the cystine recognition mechanism and capture the key conformational states of the transport cycle.”
Quoted verbatim from Structure and mechanism of human cystine exporter cystinosin.. - Study
- mechanistic · not in humans
- Population
- purified human cystinosin protein
Structure and mechanism of human cystine exporter cystinosin.2022PMID:36113465