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Catalyst

PapersPMID:35088071

Acanthopanax senticosus total flavonoids alleviate lipopolysaccharide-induced intestinal inflammation and modulate the gut microbiota in mice.

Bioscience reports2022The record ↗

findings
2
compound
1
endpoints
2
  1. Finding, very limited evidencelowersTumour necrosis factor alpha concentration
  2. Finding, very limited evidencelowersInterleukin-6 concentration
Study, every finding
animal · not in humans · 7 days
Dose studied, every finding
200, 400 or 800 mg/kg once daily by intragastric gavage for 7 days after the LPS injection

What moved

How to read these marks →
  • “Compared with the LPS model group, ASTF significantly reduced the contents of IL-1β, IL-6, PGE2 and TNF-α in each dosage group (P<0.001), and except for the content of IL-1β, all of these effects were dose-dependent.”
    • Decreases tumour necrosis factor alpha concentration

      very limited

      Population
      Male Kunming mice with intestinal inflammation induced by intraperitoneal LPS 10 mg/kg; serum TNF-α by ELISA after 7 days of treatment; all three ASTF dose groups (200, 400, 800 mg/kg) against the LPS model group
    • Decreases interleukin-6 concentration

      very limited

      Population
      Male Kunming mice with intestinal inflammation induced by intraperitoneal LPS 10 mg/kg; serum IL-6 by ELISA after 7 days of treatment; all three ASTF dose groups (200, 400, 800 mg/kg) against the LPS model group

Study record

Design
animal study, in vivo
Species
animal
Population
Male Yunnan Kunming mice, 5 weeks old, with LPS-induced intestinal inflammation (10 mg/kg LPS intraperitoneally)
Participants
50
Comparator
an active treatment / placebo
Duration
7 days
Endpoints measured
78