Papers/PMID:34421358
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway.
International journal of biological sciences2021The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
berberine — decreases body mass
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×3“These results showed at 20 weeks the body weight significantly increased in HF group compared with NCD group (P<0.01), whereas BBR significantly suppressed body weight of mice with a high-fat diet in a dose-dependent manner (P<0.01).”
Quoted verbatim from Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway.. - Study
- animal · not in humans
- Dose
- 25 or 100 mg/kg daily by gavage, from 14 to 20 weeks of age
- Population
- Male C57BL/6J mice fed a high-fat diet; berberine 25 and 100 mg/kg versus saline gavage, body weight at 20 weeks of age
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway.2021PMID:34421358Permalink