Papers/PMID:33543655
A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments.
Integrative cancer therapies2021The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
melatonin — decreases subjective fatigue
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“However, after intervention, the mean fatigue score and severity of fatigue were significantly lower in the intervention group (P <.05; Table 2).”
Quoted verbatim from A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments.. - Study
- RCT
- Dose
- 18 mg oral melatonin once daily at night, from 1 week before adjuvant chemotherapy until 1 month after completing adjuvant radiotherapy
- Population
- Women with stage I to III invasive breast cancer receiving adjuvant chemotherapy and radiotherapy; all patients in both arms received the same chemotherapy and radiotherapy; placebo was cellulose tablets
A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments.2021PMID:33543655Permalink