Papers/PMID:33356467
Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials.
Critical reviews in food science and nutrition2022The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
Zn(2+) — decreases C-reactive protein concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×5“There was a significant reduction of circulating CRP (WMD: -32.4; 95% CI: -44.45 to -19.62, p < 0.001), hs-CRP (WMD: -0.95; 95% CI: -1.01 to -0.89, p < 0.001), Neutrophil levels (SMD: -0.46; 95% CI: -0.90 to -0.01, p = 0.043), following zinc supplementation.”
Quoted verbatim from Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in randomised trials of zinc supplementation (35 RCTs, 1995 participants across all immune outcomes)
Effect -32.4 mean difference, 95% CI -44.45 to -19.62
Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials.2022PMID:33356467Permalink
What did not
1 finding
Zn(2+) — no detected effect on total leukocyte count
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Zinc supplementation had no significant effect on WBC (SMD: -0.66; 95% CI: -1.67 to 0.36, p = 0.204), lymphocyte (WMD: 1.86; 95% CI: -0.86 to 4.58, p = 0.181), monocyte levels (SMD: -0.16; 95% CI: -0.07 to 0.39, p = 0.167), CD3 (SMD: 0.37; 95% CI: -0.49 to 1.22, p = 0.399).”
Quoted verbatim from Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in randomised trials of zinc supplementation (35 RCTs, 1995 participants across all immune outcomes)
Effect -0.66 standardised mean difference, 95% CI -1.67 to 0.36
Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials.2022PMID:33356467Permalink