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Papers/PMID:33298054

Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study.

BMC medicine2020The record

1 finding · 1 compound · 1 endpoint · 1 null

What it reported

How to read these marks

Every finding here is a null result.

What did not

1 finding

  • cyanocob(III)alamin — no detected effect on all-cause mortality

    Evidence strength: limited.FindingNull result
    “In univariable Cox regression analyses, we found a significant association of log2 MMA with mortality (HR 1.67 (95% CI 1.25–2.22), P < 0.001) and eGFR (per 10 mL/min/1.73 m2) with mortality (0.73 (0.62–0.85), P < 0.001), while log2 vitamin B12 was not significantly associated with mortality (0.74 (0.49–1.11), P = 0.1).”
    Quoted verbatim from Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study..
    Study
    cohort
    Participants
    1,533
    Population
    1533 community-dwelling Dutch adults aged 60-75 years in the Lifelines-MINUTHE subcohort; baseline serum vitamin B12 (per doubling) against all-cause mortality over a median 5.3 years; univariable Cox analysis

    Effect 0.74 hazard ratio, 95% CI 0.49 to 1.11

    Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study.2020PMID:3329805410.1186/s12916-020-01853-xIndustry fundedPermalink