Papers/PMID:32721845
Implementation of magnesium sulphate as an adjunct to multimodal analgesic approach for perioperative pain control in lumbar laminectomy surgery: A randomized placebo-controlled clinical trial.
Clinical neurology and neurosurgery2020The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
magnesium(2+) — increases time to first postoperative analgesic request
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Magnesium reduced intraoperative remifentanil consumption and prolonged the time-interval to first rescue analgesia (p < 0.01).”
Quoted verbatim from Implementation of magnesium sulphate as an adjunct to multimodal analgesic approach for perioperative pain control in lumbar laminectomy surgery: A randomized placebo-controlled clinical trial.. - Study
- RCT
- Dose
- 20 mg/kg iv bolus before anaesthesia induction, then 20 mg/kg/h continuous infusion until surgery completion
- Population
- Adults undergoing lumbar laminectomy under desflurane anaesthesia with a multimodal analgesic plan; magnesium sulphate versus saline
Implementation of magnesium sulphate as an adjunct to multimodal analgesic approach for perioperative pain control in lumbar laminectomy surgery: A randomized placebo-controlled clinical trial.2020PMID:32721845Permalink
magnesium(2+) — decreases visual analogue scale pain intensity
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Postoperative analgesics consumption in morphine iv equivalents (mean difference -9.24 [95 %CI -13.31, -5.17] mg; p = 0.001) and VAS scores at all-time points of assessment were lower in magnesium group; this effect peaked at 4 h (mean difference -2.15 [95 %CI -3.21,-1.09; p = 0.001].”
Quoted verbatim from Implementation of magnesium sulphate as an adjunct to multimodal analgesic approach for perioperative pain control in lumbar laminectomy surgery: A randomized placebo-controlled clinical trial.. - Study
- RCT
- Duration
- 1 day
- Dose
- 20 mg/kg iv bolus before anaesthesia induction, then 20 mg/kg/h continuous infusion until surgery completion
- Population
- Adults undergoing lumbar laminectomy under desflurane anaesthesia with a multimodal analgesic plan; magnesium sulphate versus saline
Implementation of magnesium sulphate as an adjunct to multimodal analgesic approach for perioperative pain control in lumbar laminectomy surgery: A randomized placebo-controlled clinical trial.2020PMID:32721845Permalink