PapersPMID:32560181
Effects of L-Phenylalanine on Energy Intake and Glycaemia-Impacts on Appetite Perceptions, Gastrointestinal Hormones and Gastric Emptying in Healthy Males.
- findings
- 3
- compound
- 1
- endpoints
- 3
- Study, every finding
- RCT · 1 day
What moved
How to read these marks →“Phe-10 g, but not Phe-5 g, reduced peak glucose compared with control (p = 0.017).”
- Dose studied
- 10 g L-phenylalanine as a single 100-mL intragastric bolus via nasogastric tube, suspended in ORA-Plus, 30 min before the mixed-nutrient drink
- Population
- Healthy normal-weight young men, part B, randomised double-blind three-way crossover; peak plasma glucose after a 300-mL mixed-nutrient drink (Ensure Plus, 400 kcal) taken 30 min after the intragastric bolus; Phe-10 g arm against control suspension
“Phe-10 g, but not Phe-5 g, reduced energy intake compared with control (p = 0.012; Table 1).”
- Dose studied
- 10 g L-phenylalanine as a single 100-mL intragastric bolus via nasogastric tube, suspended in ORA-Plus, 30 min before the buffet meal
- Population
- Healthy normal-weight young men, part A, randomised double-blind three-way crossover; Phe-10 g arm against control suspension without phenylalanine; energy intake at a buffet meal 30 min after the intragastric bolus
- Increases plasma glucagon
moderate
“Phe-10 g increased (p = 0.002), while Phe-5 g tended to increase (p = 0.097), plasma glucagon AUC−1 to −120 min, compared with control.”
- Dose studied
- 10 g L-phenylalanine as a single 100-mL intragastric bolus via nasogastric tube, suspended in ORA-Plus, 30 min before the mixed-nutrient drink
- Population
- Healthy normal-weight young men, part B, randomised double-blind three-way crossover; plasma glucagon AUC over 120 min after a mixed-nutrient drink preceded by the intragastric bolus; Phe-10 g arm against control suspension
Study record
- Design
- crossover trial / randomised controlled trial
- Species
- human
- Population
- healthy normal-weight males, two parts (A: appetite and energy intake; B: glycaemia and gastric emptying), 16 per part
- Participants
- 16
- Comparator
- placebo
- Duration
- not reported
- Endpoints measured
- 56