Papers/PMID:32231310
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.
Nature cell biology2020The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-cystine — is transported by SLC7A11
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Once cystine is transported into cells through SLC7A11, it is reduced to cysteine, a reaction which consumes NADPH.”
Quoted verbatim from Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.. - Study
- in vitro · not in humans
- Population
- human renal cancer cell lines (UMRC6, 786-O) with SLC7A11 overexpression
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.2020PMID:32231310An author is affiliated with a producerPermalink