L-cystine/Finding
One finding, on its own
A single claim from the graph, with the grade computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Is transported by SLC7A11
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Once cystine is transported into cells through SLC7A11, it is reduced to cysteine, a reaction which consumes NADPH.”
Quoted verbatim from Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.. - Study
- in vitro · not in humans
- Population
- human renal cancer cell lines (UMRC6, 786-O) with SLC7A11 overexpression
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.2020PMID:32231310An author is affiliated with a producerPermalink
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To cite this finding: https://catalystproject.ai/e/01M3PFXER4V1JW33W3W2YYBC25