Papers/PMID:31489695
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.
British journal of clinical pharmacology2020The record
3 findings · 1 compound · 3 endpoints · 3 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
3 findings
hesperidin — no detected effect on fasting blood glucose
Evidence strength: very limited.FindingNull result“The results showed that hesperidin had no significant effect on serum fasting blood glucose (weighted mean difference [WMD] = -1.10 mg/dL, 95% CI: -3.79, 1.57), plasma insulin (WMD = -0.01 μU/mL, 95% CI: -1.20, 1.19), glycated haemoglobin A1c (WMD = -0.04%, 95% CI: -0.14, 0.04), homeostasis model assessment for insulin resistance (WMD = 0.117, 95% CI: -0.06, 0.29) and quantitative insulin sensitivity check index (WMD = 0.135; 95% CI: -0.13, 0.39), with no significant between-study heterogeneity.”
Quoted verbatim from Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.. - Study
- meta-analysis
- Population
- Adults; systematic review and meta-analysis of six randomized controlled trials of hesperidin supplementation
Effect -1.1 mean difference, 95% CI -3.79 to 1.57
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.2020PMID:3148969510.1111/bcp.14120Permalink
hesperidin — no detected effect on glycated haemoglobin (HbA1c)
Evidence strength: very limited.FindingNull result“The results showed that hesperidin had no significant effect on serum fasting blood glucose (weighted mean difference [WMD] = -1.10 mg/dL, 95% CI: -3.79, 1.57), plasma insulin (WMD = -0.01 μU/mL, 95% CI: -1.20, 1.19), glycated haemoglobin A1c (WMD = -0.04%, 95% CI: -0.14, 0.04), homeostasis model assessment for insulin resistance (WMD = 0.117, 95% CI: -0.06, 0.29) and quantitative insulin sensitivity check index (WMD = 0.135; 95% CI: -0.13, 0.39), with no significant between-study heterogeneity.”
Quoted verbatim from Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.. - Study
- meta-analysis
- Population
- Adults; systematic review and meta-analysis of six randomized controlled trials of hesperidin supplementation
Effect -0.04 mean difference, 95% CI -0.14 to 0.04
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.2020PMID:3148969510.1111/bcp.14120Permalink
hesperidin — no detected effect on HOMA-IR
Evidence strength: very limited.FindingNull result“The results showed that hesperidin had no significant effect on serum fasting blood glucose (weighted mean difference [WMD] = -1.10 mg/dL, 95% CI: -3.79, 1.57), plasma insulin (WMD = -0.01 μU/mL, 95% CI: -1.20, 1.19), glycated haemoglobin A1c (WMD = -0.04%, 95% CI: -0.14, 0.04), homeostasis model assessment for insulin resistance (WMD = 0.117, 95% CI: -0.06, 0.29) and quantitative insulin sensitivity check index (WMD = 0.135; 95% CI: -0.13, 0.39), with no significant between-study heterogeneity.”
Quoted verbatim from Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.. - Study
- meta-analysis
- Population
- Adults; systematic review and meta-analysis of six randomized controlled trials of hesperidin supplementation
Effect 0.117 mean difference, 95% CI -0.06 to 0.29
Hesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.2020PMID:3148969510.1111/bcp.14120Permalink