Papers/PMID:30878985
Morphine in acute coronary syndrome: systematic review and meta-analysis.
BMJ open2019The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
morphine — increases all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Adjusted pooled results showed an increased risk of in-hospital mortality in the morphine group (RR 1.45; 95% CI 1.10 to 1.91; I2=0%).”
Quoted verbatim from Morphine in acute coronary syndrome: systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- morphine 2-10 mg intravenous or intramuscular in the RCTs; dose and route not reported in six observational studies
- Population
- Patients with acute coronary syndrome (STEMI and NSTE-ACS); four RCTs and seven observational studies pooled, adjusted estimates; horizon in-hospital
Effect 1.45 risk ratio, 95% CI 1.1 to 1.91
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