Papers/PMID:30237578
Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.
Scientific reports2018The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
astaxanthin — decreases alanine aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) were higher in ethanol-fed mice than pair-fed mice, but these values were decreased in ethanol with AXT-fed mice.”
Quoted verbatim from Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 0.2, 2 or 20 mg/kg daily by oral gavage in olive oil
- Population
- Male C57BL/6 mice (n = 8 per group) on a chronic-plus-binge ethanol model; AXT 0.2, 2 or 20 mg/kg by oral gavage for 10 days versus ethanol-fed mice without AXT
Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.2018PMID:30237578Permalink
astaxanthin — decreases aspartate aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Serum levels of aspartate transaminase (AST) and alanine transaminase (ALT) were higher in ethanol-fed mice than pair-fed mice, but these values were decreased in ethanol with AXT-fed mice.”
Quoted verbatim from Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 0.2, 2 or 20 mg/kg daily by oral gavage in olive oil
- Population
- Male C57BL/6 mice (n = 8 per group) on a chronic-plus-binge ethanol model; AXT 0.2, 2 or 20 mg/kg by oral gavage for 10 days versus ethanol-fed mice without AXT
Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.2018PMID:30237578Permalink
astaxanthin — inhibits STAT3
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Furthermore, ethanol-induced p-STAT3 expression was lowered in ethanol with AXT-fed mice than ethanol-fed mice.”
Quoted verbatim from Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 0.2, 2 or 20 mg/kg daily by oral gavage for 10 days
- Population
- Male C57BL/6 mice on a chronic-plus-binge ethanol model; liver phospho-STAT3 by Western blot, AXT-fed versus ethanol-fed
Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity.2018PMID:30237578Permalink