Papers/PMID:29912983
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
PLoS medicine2018The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
melatonin — decreases pittsburgh Sleep Quality Index global score
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“Mean PSQI score post treatment was lower in the melatonin group compared to placebo (P = 0.037).”
Quoted verbatim from Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 0.5 mg fast-release melatonin orally 1 h before desired bedtime, at least 5 nights per week
- Population
- 116 randomised adults aged 16 to 65 with delayed sleep-wake phase disorder and delayed melatonin rhythm; behavioural sleep-wake scheduling in both arms; post-treatment at 4 weeks
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.2018PMID:29912983An author is affiliated with a producerPermalink
melatonin — decreases insomnia Severity Index (ISI) total score
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Following treatment, the melatonin group reported a lower ISI score (P = 0.035) and included more individuals reporting absent insomnia symptoms on the ISI (P = 0.008).”
Quoted verbatim from Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 0.5 mg fast-release melatonin orally 1 h before desired bedtime, at least 5 nights per week
- Population
- 116 randomised adults aged 16 to 65 with delayed sleep-wake phase disorder and delayed melatonin rhythm; behavioural sleep-wake scheduling in both arms; post-treatment at 4 weeks
Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.2018PMID:29912983An author is affiliated with a producerPermalink