Papers/PMID:29713967
Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.
Clinical rheumatology2018The record
1 finding drawn from this paper, on 1 compound across 1 endpoint, 1 of them null.
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
glucosamine — no detected effect on WOMAC pain subscale
LikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result“As for WOMAC pain scores (Fig., the summarized effect size was − 0.04 ([95% CI] − 0.13, 0.06), suggesting a favorable but not significant effect of glucosamine on knee pain as measured by WOMAC.”
Quoted verbatim from Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- pooled across trials: five used a sulfate salt of glucosamine (two of them Rottapharm/Madaus crystalline glucosamine sulfate), six used the hydrochloride salt, one used N-acetylated glucosamine, unclear for the rest; 1500 mg/day in most studies per the Discussion, per-trial doses not tabulated in Table 1
- Population
- Adults with knee osteoarthritis in randomised placebo-controlled trials published between 2003 and 2016; the pooled trials include both glucosamine given alone and commercial supplements combining glucosamine with other components, chondroitin among them.
Effect -0.04 standardised mean difference, 95% CI -0.13 to 0.06
Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.2018PMID:29713967