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Catalyst

PapersPMID:29514999

Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.

Science translational medicine2018The record ↗

  1. Finding, very limited evidencelowersAsymmetric dimethylarginine (ADMA) concentration

What moved

1 findingHow to read these marks →
  • Decreases asymmetric dimethylarginine (ADMA) concentration

    very limited

    “Malaria-infected dams receiving L-arginine supplementation showed reduced serum ADMA (P < 0.01; Fig. 5B) and SDMA (P < 0.05; Fig. 5C), although there was no significant difference in L-arginine/ADMA ratio (P > 0.05; Fig. 5D) compared with the control group.”
    Study
    animal · not in humans
    Dose studied
    1.2% L-arginine monohydrochloride in drinking water versus regular drinking water, started before pregnancy and at least 13 days before infection
    Population
    Pregnant BALB/c mice infected with Plasmodium berghei ANKA on gestational day 13 (experimental malaria in pregnancy), serum at gestational day 19; malaria-infected dams only

Study record

Design
animal study, in vivo / cohort study
Species
mixed
Population
Primigravid Malawian women (plasma L-arginine, ADMA, SDMA measured, nothing dosed) and BALB/c mice with experimental malaria in pregnancy given L-arginine monohydrochloride in drinking water
Participants
384
Comparator
observational / placebo
Duration
not reported
Endpoints measured
68