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Catalyst

PapersPMID:29330660

Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects.

European journal of nutrition2019The record ↗

  1. Finding, limited evidenceno difference foundFlow-mediated dilation

No finding here moved its endpoint.

What did not

1 findingHow to read these marks →
  • “In the fasting condition, theobromine consumption did not change FMD, brachial artery diameter, and RHI.”
    Study
    crossover
    Duration
    4 weeks
    Dose studied
    500 mg theobromine per day in a 20 mL drink at breakfast for 4 weeks, versus placebo drink, crossover with 4-week washout
    Population
    Overweight and obese men and women aged 45-70 years with HDL-C below the 50th percentile of the Dutch population; fasting measurement after 4 weeks of each treatment period

Study record

Design
crossover trial
Species
human
Population
Healthy overweight or slightly obese men and women with low HDL-C
Participants
44
Comparator
placebo
Duration
28 days
Endpoints measured
29