Papers/PMID:29121675
Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice.
PloS one2017The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
astaxanthin — decreases alanine aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“In addition, the levels of AST and ALT were elevated, and were effectively reduced in the ASTX group compared with the IR group.”
Quoted verbatim from Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice.. - Study
- animal · not in humans
- Duration
- 2 days
- Dose
- 25 mg/kg by oral gavage three times, at 48 h, 24 h and 40 min before ischemia
- Population
- Male C57BL/6 mice with diet-induced steatotic liver (methionine- and choline-deficient high-fat diet, 21 days), 15 min ischemia and 3 h reperfusion; ASTX versus olive oil by gavage before ischemia-reperfusion
Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice.2017PMID:29121675Permalink
astaxanthin — decreases aspartate aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“In addition, the levels of AST and ALT were elevated, and were effectively reduced in the ASTX group compared with the IR group.”
Quoted verbatim from Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice.. - Study
- animal · not in humans
- Duration
- 2 days
- Dose
- 25 mg/kg by oral gavage three times, at 48 h, 24 h and 40 min before ischemia
- Population
- Male C57BL/6 mice with diet-induced steatotic liver (methionine- and choline-deficient high-fat diet, 21 days), 15 min ischemia and 3 h reperfusion; ASTX versus olive oil by gavage before ischemia-reperfusion
Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice.2017PMID:29121675Permalink