Papers/PMID:29103346
Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2019The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
Zn(2+) — decreases all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×5“Overall, compared with control intervention in neonatal sepsis, zinc supplementation is able to significantly reduce mortality rate (risk ratio (RR) = 0.48; 95% confidence intervals (CIs) = 0.25-0.94; p = .03) and improve serum zinc (mean difference (MD) = 81.97; 95% CI = 34.57-129.37; p = .0007), but has no remarkable influence on hospital stay (MD = -4.51; 95% CI = -15.08 to 6.05; p = .40) and the number of expired patients (RR = 0.63; 95% CI = 0.24-1.65; p = .35).”
Quoted verbatim from Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Neonates with sepsis; four pooled randomised trials of zinc supplementation against a control intervention
Effect 0.48 risk ratio, 95% CI 0.25 to 0.94
Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis.2019PMID:29103346Permalink
What did not
1 finding
Zn(2+) — no detected effect on hospital length of stay
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×1“Overall, compared with control intervention in neonatal sepsis, zinc supplementation is able to significantly reduce mortality rate (risk ratio (RR) = 0.48; 95% confidence intervals (CIs) = 0.25-0.94; p = .03) and improve serum zinc (mean difference (MD) = 81.97; 95% CI = 34.57-129.37; p = .0007), but has no remarkable influence on hospital stay (MD = -4.51; 95% CI = -15.08 to 6.05; p = .40) and the number of expired patients (RR = 0.63; 95% CI = 0.24-1.65; p = .35).”
Quoted verbatim from Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Neonates with sepsis; pooled randomised trials of zinc supplementation against a control intervention
Effect -4.51 mean difference, 95% CI -15.08 to 6.05
Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis.2019PMID:29103346Permalink