Papers/PMID:28223437
Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization.
Journal of the American Heart Association2017The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
all-cis-5,8,11,14,17-icosapentaenoic acid — decreases all-cause mortality
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“The incidence of postinfarct mortality was significantly lower in the MI+EPA group than in the MI+PBS group (59.3% vs 41.2%, P=0.0361).”
Quoted verbatim from Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization.. - Study
- animal · not in humans
- Duration
- 8 weeks
- Dose
- EPA ethyl ester (more than 99% purity) 1 g/kg/day by oral gavage, once daily for 4 weeks before and 4 weeks after infarction; control received PBS by gavage
- Population
- Male 10-week-old C57BL/6J mice with myocardial infarction induced by left coronary artery ligation, followed 28 days after infarction
Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization.2017PMID:28223437Permalink