Papers/PMID:27629750
Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.
Journal of translational medicine2016The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
berberine — decreases body mass
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“BBR exhibited greater decreases in body weight, BMI, waist, HFC, serum cholesterol and triglycerides compared with LSI alone (Additional file 1: Table S1), which demonstrates a clearly significant benefit of BBR on metabolism.”
Quoted verbatim from Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.. - Study
- RCT
- Duration
- 4 months
- Dose
- berberine 0.5 g three times daily, 30 min before meals
- Population
- Adults with nonalcoholic fatty liver disease and impaired glucose regulation or type 2 diabetes; lifestyle intervention (diet and exercise) given to both arms, berberine added in one; 80-patient lipidomics subsample (41 berberine, 39 lifestyle alone)
Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.2016PMID:27629750Permalink
berberine — decreases body mass index
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×3“BBR exhibited greater decreases in body weight, BMI, waist, HFC, serum cholesterol and triglycerides compared with LSI alone (Additional file 1: Table S1), which demonstrates a clearly significant benefit of BBR on metabolism.”
Quoted verbatim from Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.. - Study
- RCT
- Duration
- 4 months
- Dose
- berberine 0.5 g three times daily, 30 min before meals
- Population
- Adults with nonalcoholic fatty liver disease and impaired glucose regulation or type 2 diabetes; lifestyle intervention (diet and exercise) given to both arms, berberine added in one; 80-patient lipidomics subsample (41 berberine, 39 lifestyle alone)
Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.2016PMID:27629750Permalink
berberine — decreases triglycerides
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“BBR exhibited greater decreases in body weight, BMI, waist, HFC, serum cholesterol and triglycerides compared with LSI alone (Additional file 1: Table S1), which demonstrates a clearly significant benefit of BBR on metabolism.”
Quoted verbatim from Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.. - Study
- RCT
- Duration
- 4 months
- Dose
- berberine 0.5 g three times daily, 30 min before meals
- Population
- Adults with nonalcoholic fatty liver disease and impaired glucose regulation or type 2 diabetes; lifestyle intervention (diet and exercise) given to both arms, berberine added in one; 80-patient lipidomics subsample (41 berberine, 39 lifestyle alone)
Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease.2016PMID:27629750Permalink