Papers/PMID:26023842
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.
Marine drugs2015The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
astaxanthin — decreases alanine aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Following ASX treatment (30 mg/kg or 60 mg/kg), ALT and AST decreased in a dose-dependent manner.”
Quoted verbatim from Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 30 mg/kg or 60 mg/kg for 14 days before ischemia reperfusion
- Population
- Mice with hepatic ischemia reperfusion injury, pretreated with astaxanthin 30 or 60 mg/kg for 14 days, compared with the untreated ischemia reperfusion group
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.2015PMID:26023842Permalink
astaxanthin — decreases aspartate aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Following ASX treatment (30 mg/kg or 60 mg/kg), ALT and AST decreased in a dose-dependent manner.”
Quoted verbatim from Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 30 mg/kg or 60 mg/kg for 14 days before ischemia reperfusion
- Population
- Mice with hepatic ischemia reperfusion injury, pretreated with astaxanthin 30 or 60 mg/kg for 14 days, compared with the untreated ischemia reperfusion group
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice.2015PMID:26023842Permalink