Papers/PMID:25978046
Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial.
PloS one2015The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
Melissa officinalis — no detected effect on alanine aminotransferase
Evidence strength: moderate.FindingNull result“The serum levels of AST, ALT, LDH, γ-GTP, and T-Bil (indicators of liver function) or those of BUN and Cr (indicators of kidney function) were not significantly affected by any of the interventions (M. officinalis extract containing 100 mg, 250 mg, 500 mg RA, or placebo) (Table 2).”
Quoted verbatim from Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial.. - Study
- crossover
- Duration
- 2 days
- Dose
- single oral dose of extract containing 100, 250 or 500 mg rosmarinic acid versus placebo capsules
- Population
- Healthy volunteers aged 20-31 years, single dose in a fasted-state Latin-square crossover with 10-day washout; safety bloods taken 48 hours after dosing
Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial.2015PMID:2597804610.1371/journal.pone.0126422Permalink
Melissa officinalis — no detected effect on aspartate aminotransferase
Evidence strength: moderate.FindingNull result“The serum levels of AST, ALT, LDH, γ-GTP, and T-Bil (indicators of liver function) or those of BUN and Cr (indicators of kidney function) were not significantly affected by any of the interventions (M. officinalis extract containing 100 mg, 250 mg, 500 mg RA, or placebo) (Table 2).”
Quoted verbatim from Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial.. - Study
- crossover
- Duration
- 2 days
- Dose
- single oral dose of extract containing 100, 250 or 500 mg rosmarinic acid versus placebo capsules
- Population
- Healthy volunteers aged 20-31 years, single dose in a fasted-state Latin-square crossover with 10-day washout; safety bloods taken 48 hours after dosing
Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial.2015PMID:2597804610.1371/journal.pone.0126422Permalink