Papers/PMID:25008853
Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians' Health Study II randomized trial.
The American journal of clinical nutrition2014The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
α-tocopherol — no detected effect on prostate cancer incidence
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×3“In comparison with placebo, vitamin E supplementation had no effect on the incidence of prostate cancer (HR: 0.99; 95% CI: 0.89, 1.10) or total cancers (HR: 1.02; 95% CI: 0.95, 1.10).”
Quoted verbatim from Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians' Health Study II randomized trial.. - Study
- RCT
- Participants
- 14,641
- Dose
- 400 IU of vitamin E every other day
- Population
- 14,641 US male physicians aged 50 or older in the Physicians' Health Study II, 2x2 factorial with vitamin C given across both vitamin E arms; trial plus posttrial observational follow-up
Effect 0.99 hazard ratio, 95% CI 0.89 to 1.1
Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians' Health Study II randomized trial.2014PMID:25008853Permalink