Papers/PMID:22854402
High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial.
The American journal of clinical nutrition2012The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
calciol — increases serum 25-hydroxyvitamin D concentration
Evidence strength: very limited.Findingreplicated ×33“By 12 wk, serum 25(OH)D increased in the vitamin D group only [baseline (mean ± SD): 26.7 ± 6.8 to 42.8 ± 16.9 ng/mL; P < 0.05] and remained elevated at 1 y (group-by-time interaction: P < 0.001).”
Quoted verbatim from High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 12 months
- Dose
- oral cholecalciferol 50,000 IU weekly for 12 weeks then 50,000 IU every other week for 40 weeks, versus matching placebo
- Population
- Adults with early chronic kidney disease, stages 2 and 3
High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial.2012PMID:2285440210.3945/ajcn.112.040642Permalink