Papers/PMID:21856809
Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2011The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
L-ascorbic acid — no detected effect on total leukocyte count
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Ascorbic acid did not affect the natural course of inflammatory marker rise for C-reactive protein (CRP) concentration, white blood cell (WBC) count, or fibrinogen concentration versus placebo at any evaluated time point (p > 0.05 for all intergroup comparisons).”
Quoted verbatim from Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery.. - Study
- RCT
- Duration
- 5 days
- Dose
- 2-g loading dose then 500 mg every 12 hours, evening before surgery and four days postoperatively
- Population
- Adults undergoing cardiopulmonary bypass graft or valve replacement surgery; postoperative days 1-4
Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery.2011PMID:21856809Permalink
L-ascorbic acid — no detected effect on C-reactive protein concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Ascorbic acid did not affect the natural course of inflammatory marker rise for C-reactive protein (CRP) concentration, white blood cell (WBC) count, or fibrinogen concentration versus placebo at any evaluated time point (p > 0.05 for all intergroup comparisons).”
Quoted verbatim from Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery.. - Study
- RCT
- Duration
- 5 days
- Dose
- 2-g loading dose then 500 mg every 12 hours, evening before surgery and four days postoperatively
- Population
- Adults undergoing cardiopulmonary bypass graft or valve replacement surgery; postoperative days 1-4
Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery.2011PMID:21856809Permalink