Papers/PMID:21346065
Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.
The Journal of clinical endocrinology and metabolism2011The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
hesperidin — increases flow-mediated dilation
Evidence strength: very limited.Finding“In the clinical study, when compared with placebo, hesperidin treatment increased flow-mediated dilation (10.26 ± 1.19 vs. 7.78 ± 0.76%; P = 0.02) and reduced concentrations of circulating inflammatory biomarkers (high-sensitivity C-reactive protein, serum amyloid A protein, soluble E-selectin).”
Quoted verbatim from Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.. - Study
- crossover
- Duration
- 3 weeks
- Dose
- 500 mg once daily for 3 weeks
- Population
- Adults with metabolic syndrome (n = 24); randomized placebo-controlled double-blind crossover trial of oral hesperidin
Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.2011PMID:2134606510.1210/jc.2010-2879Permalink
hesperidin — decreases C-reactive protein concentration
Evidence strength: very limited.Finding“In the clinical study, when compared with placebo, hesperidin treatment increased flow-mediated dilation (10.26 ± 1.19 vs. 7.78 ± 0.76%; P = 0.02) and reduced concentrations of circulating inflammatory biomarkers (high-sensitivity C-reactive protein, serum amyloid A protein, soluble E-selectin).”
Quoted verbatim from Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.. - Study
- crossover
- Duration
- 3 weeks
- Dose
- 500 mg once daily for 3 weeks
- Population
- Adults with metabolic syndrome (n = 24); randomized placebo-controlled double-blind crossover trial of oral hesperidin
Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.2011PMID:2134606510.1210/jc.2010-2879Permalink