Papers/PMID:18997197
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.
JAMA2008The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
L-ascorbic acid — no detected effect on incidence of cardiovascular disease (composite)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“There was no effect of vitamin C on the primary endpoint of major cardiovascular events (HR, 0.99; 95% CI, 0.89–1.11; P=0.91) (Table 2).”
Quoted verbatim from Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.. - Study
- RCT
- Dose
- 500 mg synthetic ascorbic acid daily
- Population
- 14,641 US male physicians aged 50 years or older; vitamin E, multivitamin and beta-carotene were randomised independently in a factorial design and balanced across the vitamin C and placebo arms
Effect 0.99 hazard ratio, 95% CI 0.89 to 1.11
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.2008PMID:18997197Industry fundedPermalink