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Subsystem: Valine, leucine, and isoleucine metabolism Remove
1–50 of 53 reactions in Valine, leucine, and isoleucine metabolism
H+[c] + methylmalonyl-CoA[c] = CO2[c] + propanoyl-CoA[c]
Left to rightBalancedEC 4.1.1.9Human-GEM MAR01521
H+[x] + methylmalonyl-CoA[x] = CO2[x] + propanoyl-CoA[x]
Left to rightBalancedEC 4.1.1.9Human-GEM MAR01522
H2O[m] + methylmalonyl-CoA[m] = CoA[m] + H+[m] + methylmalonate[m]
ReversibleBalancedEC 3.1.2.17Human-GEM MAR02146
2-methylacetoacetyl-CoA[m] + CoA[m] = acetyl-CoA[m] + propanoyl-CoA[m]
Left to rightBalancedEC 2.3.1.16Human-GEM MAR03206
ATP[m] + HCO3-[m] + propanoyl-CoA[m] = ADP[m] + H+[m] + methylmalonyl-CoA[m] + Pi[m]
Left to rightBalancedEC 6.4.1.3
methylmalonyl-CoA[m] = (R)-methylmalonyl-CoA[m]
Left to rightBalancedEC 5.1.99.1Human-GEM MAR03213
(R)-methylmalonyl-CoA[m] = succinyl-CoA[m]
Left to rightBalancedEC 5.4.99.2Human-GEM MAR03215
AKG[m] + valine[m] = 3-methyl-2-oxobutyrate[m] + glutamate[m]
Left to rightBalancedEC 2.6.1.42Human-GEM MAR03744
AKG[c] + valine[c] = 3-methyl-2-oxobutyrate[c] + glutamate[c]
Left to rightBalancedEC 2.6.1.42Human-GEM MAR03747
H2O[m] + methacrylyl-CoA[m] = 3-hydroxyisobutyryl-CoA[m]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR03753
3-hydroxyisobutyryl-CoA[m] + H2O[m] = 3-hydroxyisobutyrate[m] + CoA[m] + H+[m]
Left to rightBalancedEC 3.1.2.4Human-GEM MAR03755
3-hydroxyisobutyrate[m] + NAD+[m] = 2-methyl-3-oxopropanoate[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.1.1.31, 1.1.1.35Human-GEM MAR03757
2-methyl-3-oxopropanoate[m] + H2O[m] + NAD+[m] = 2 H+[m] + methylmalonate[m] + NADH[m]
Left to rightBalancedEC 1.2.1.3, 1.2.3.1Human-GEM MAR03759
2-methyl-3-oxopropanoate[m] + CoA[m] + NAD+[m] = (R)-methylmalonyl-CoA[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.2.1.18Human-GEM MAR03761
CoA[m] + H+[m] + methylmalonate[m] = (R)-methylmalonyl-CoA[m] + H2O[m]
Left to rightBalancedEC 3.1.2.17, 1.2.1.18Human-GEM MAR03763
AKG[m] + leucine[m] = 4-methyl-2-oxopentanoate[m] + glutamate[m]
Left to rightBalancedEC 2.6.1.42, 2.6.1.6Human-GEM MAR03765
3-methylcrotonyl-CoA[m] + ATP[m] + HCO3-[m] = 3-methylglutaconyl-CoA[m] + ADP[m] + H+[m] + Pi[m]
Left to rightBalancedEC 6.4.1.4Human-GEM MAR03773
3-methylglutaconyl-CoA[m] + H2O[m] = HMG-CoA[m]
ReversibleBalancedEC 4.2.1.18Human-GEM MAR03775
AKG[c] + isoleucine[c] = 2-oxo-3-methylvalerate[c] + glutamate[c]
Left to rightBalancedEC 2.6.1.42Human-GEM MAR03777
AKG[m] + isoleucine[m] = 2-oxo-3-methylvalerate[m] + glutamate[m]
Left to rightBalancedEC 2.6.1.42Human-GEM MAR03778
H2O[m] + tiglyl-CoA[m] = (S)-3-hydroxy-2-methylbutyryl-CoA[m]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR03785
2-methyl-3-oxopropanoate[c] + H2O[c] + O2[c] = H+[c] + H2O2[c] + methylmalonate[c]
Left to rightBalancedEC 1.2.3.1Human-GEM MAR03790
2-methyl-3-oxopropanoate[m] + glutamate[m] = AKG[m] + D-3-amino-isobutanoate[m]
ReversibleBalancedEC 2.6.1.22, 2.6.1.40Human-GEM MAR03792
2-methyl-3-oxopropanoate[m] + CoA[m] + NAD+[m] = CO2[m] + NADH[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.2.1.27Human-GEM MAR03795
AMP[m] + H+[m] + propanoyl-CoA[m] = CoA[m] + propinol adenylate[m]
ReversibleBalancedEC 6.2.1.1, 6.2.1.17Human-GEM MAR03796
(S)-3-hydroxy-2-methylbutyryl-CoA[m] + NAD+[m] = 2-methylacetoacetyl-CoA[m] + H+[m] + NADH[m]
ReversibleBalancedEC 1.1.1.178, 1.1.1.35Human-GEM MAR03823
2-methyl-3-oxopropanoate[c] + H2O[c] + NAD+[c] = 2 H+[c] + methylmalonate[c] + NADH[c]
Left to rightBalancedEC 1.2.1.3Human-GEM MAR04797
lipoamide[m] + 2-(2-methyl-1-hydroxypropyl)thiamine diphosphate[m] = S-(2-methylpropanoyl)-dihydrolipoamide[m] + thiamin-PP[m]
Left to rightBalance undeterminableEC 1.2.4.4Human-GEM MAR06416
CoA[m] + S-(2-methylpropanoyl)-dihydrolipoamide[m] = dihydrolipoamide[m] + isobutyryl-CoA[m]
ReversibleBalancedEC 2.3.1.168Human-GEM MAR06417
lipoamide[m] + 2-(2-methyl-1-hydroxybutyl)thiamine diphosphate[m] = S-(2-methylbutanoyl)-dihydrolipoamide[m] + thiamin-PP[m]
Left to rightBalance undeterminableEC 1.2.4.4Human-GEM MAR06419
CoA[m] + S-(2-methylbutanoyl)-dihydrolipoamide[m] = 2-methylbutyryl-CoA[m] + dihydrolipoamide[m]
Left to rightBalancedEC 2.3.1.168Human-GEM MAR06420
lipoamide[m] + 2-(3-methyl-1-hydroxybutyl)thiamine diphosphate[m] = S-(3-methylbutanoyl)-dihydrolipoamide[m] + thiamin-PP[m]
Left to rightBalance undeterminableEC 1.2.4.4Human-GEM MAR06421
CoA[m] + S-(3-methylbutanoyl)-dihydrolipoamide[m] = dihydrolipoamide[m] + isovaleryl-CoA[m]
Left to rightBalancedEC 2.3.1.168Human-GEM MAR06422
AKG[c] + leucine[c] = 4-methyl-2-oxopentanoate[c] + glutamate[c]
Left to rightBalancedEC 2.6.1.42, 2.6.1.6Human-GEM MAR06923
4-methyl-2-oxopentanoate[c] + O2[c] = beta-hydroxy-beta-methylbutyrate[c] + CO2[c]
Left to rightBalancedEC 1.13.11.-Human-GEM MAR06924
4-methyl-2-oxopentanoate[c] + H+[c] + NADH[c] = alpha-hydroxyisocaproic acid[c] + NAD+[c]
ReversibleBalancedEC 1.1.1.-Human-GEM MAR06925
2-methylglutaconyl-CoA[m] + ADP[m] + H+[m] + Pi[m] = ATP[m] + HCO3-[m] + tiglyl-CoA[m]
ReversibleBalancedEC 6.4.1.4Human-GEM MAR06926
2-methylglutaconic acid[m] + CoA[m] + H+[m] = 2-methylglutaconyl-CoA[m] + H2O[m]
ReversibleBalancedEC 6.4.1.4Human-GEM MAR06927
2-methyl-3-oxopropanoate[m] + glutamate[m] = AKG[m] + L-3-amino-isobutanoate[m]
ReversibleBalancedEC 2.6.1.22Human-GEM MAR08088
H+[m] + methylmalonyl-CoA[m] = CO2[m] + propanoyl-CoA[m]
Left to rightBalancedEC 4.1.1.9Human-GEM MAR08787
glycine[c] + phenylacetyl-CoA[c] = CoA[c] + H+[c] + phenylacetylglycine[c]
Left to rightBalancedEC 2.3.1.13Human-GEM MAR09941
acetyl-CoA[m] + isoleucine[m] = CoA[m] + H+[m] + Acetyl Isoleucine (Chemspider Id: 9964364)[m]
Left to rightBalancedHuman-GEM MAR10412
acetyl-CoA[m] + leucine[m] = CoA[m] + H+[m] + N-Acetylleucine[m]
Left to rightBalancedHuman-GEM MAR10416
2-oxo-3-methylvalerate[c] + H+[c] + NADH[c] = NAD+[c] + 2-Hydroxy-3-Methyl-Valerate[c]
ReversibleBalancedEC 1.1.1.27Human-GEM MAR11476
3-methyl-2-oxobutyrate[c] + H+[c] + NADH[c] = NAD+[c] + 2-Hydroxy-Isovalerate[c]
ReversibleBalancedEC 1.1.1.27Human-GEM MAR11479
(S)-3-hydroxy-2-methylbutyryl-CoA[m] + H2O[m] = CoA[m] + H+[m] + 2-Methyl-3-Hydroxy-Butyrate[m]
Left to rightBalancedHuman-GEM MAR11482
H2O[c] + HMG-CoA[c] = CoA[c] + H+[c] + 3-Hydroxy-3-Methyl-Glutarate[c]
Left to rightBalancedHuman-GEM MAR11492
3-methylglutaconyl-CoA[m] + H2O[m] = CoA[m] + H+[m] + 3-Methyl-Glutaconate[m]
Left to rightBalancedHuman-GEM MAR11495
H+[c] + NADPH[c] + 3-Methyl-Glutaconate[c] = NADP+[c] + 3-Methyl-Glutarate[c]
Left to rightBalancedHuman-GEM MAR11499
H2O[m] + 3-hydroxyisovaleryl-CoA[m] = CoA[m] + H+[m] + 3-hydroxyisovaleric acid[m]
Left to rightBalancedHuman-GEM MAR11525